• TRIUMPH is a clinical trial funded by the National Institutes of Health for children with acute liver failure

• The trial tests two different therapies compared to supportive care alone

• Many pediatric hospitals across the country are participating in the trial

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TRIUMPH is a NIH sponsored clinical trial (clinicaltrials.gov) testing two different types of therapies as compared to supportive care alone for children who do not have a treatable cause for their liver failure. The trial is testing whether medications that dampen the body’s immune response to sudden, severe liver injury will allow the liver to recover more quickly. We believe that in some patients with PALF the body mounts an inflammatory response to the liver injury that is overactive and that the resulting inflammation may be a barrier to effective healing of the liver cells. This trial is offered at 20 large pediatric hospitals across the country and will be enrolling patients between 2022 and 2025.